Lymphocytes in Islet transplantation Differences in Baseline Lymphocyte Counts and Autoreactivity are associated with Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients Short running title: Lymphocytes in Islet transplantation
نویسندگان
چکیده
1 Diabetes Research Center and UZ Brussel, 2 Department of Biostatistics, Brussels Free University-VUB, Brussels, Belgium; 3 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; 4 Department of Endocrinology, 5 Department of Surgery, Universitair Ziekenhuis Gasthuisberg, Catholic University of Leuven-KUL, Belgium; 6 Department of Surgery, Universitair Ziekenhuis Antwerpen, University of Antwerp, Belgium; 7 Juvenile Diabetes Research Foundation Center for Beta Cell Therapy in Diabetes
منابع مشابه
Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients
OBJECTIVE The metabolic outcome of islet cell transplants in type 1 diabetic patients is variable. This retrospective analysis examines whether differences in recipient characteristics at the time of transplantation are correlated with inadequate graft function. RESEARCH DESIGN AND METHODS Thirty nonuremic C-peptide-negative type 1 diabetic patients had received an intraportal islet cell graf...
متن کاملCo-Transplantation of VEGF-Expressing Human Embryonic Stem Cell Derived Mesenchymal Stem Cells to Enhance Islet Revascularization in Diabetic Nude Mice
Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. It has been shown that local delivery of vascular endothelial growth factor (VEGF) could accelerate transplanted islet revasculari...
متن کاملIntroducing a New Experimental Islet Transplantation Model using Biomimetic Hydrogel and a Simple High Yield Islet Isolation Technique
Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
متن کاملاستفاده از مهار کننده فاکتور نسخه‌برداری NF - κB در جزایر پانکراس
Background: Pancreatic islet transplantation has been reported as an appropriate method for treatment of type I diabetes patients, however there are strong indications that cytokine and chemokines secreted from transplanted islets play an important role in islet graft rejection in different stage post-transplantation. The NF-kB signaling pathway is activated in response to the stress resulted f...
متن کاملImmunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes
Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces insulin independence in patients with type 1 diabetes. This study aimed to investigate how clinical outcomes may associate with the immunological status, especially concerning the balance between immunoregulation and autoreactivity. Twenty-one type 1 diabetes patients were monitored after AHSCT and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009